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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

Kevin R. Parker, Denis Migliorini, Eric Perkey, Kathryn E. Yost, Aparna Bhaduri, Puneet Bagga, Mohammad Haris, Neil Wilson, Fang Liu, Khatuna Gabunia, John Scholler, Thomas J. Montine, Vijay Bhoj, Ravinder Reddy, Suyash Mohan, Ivan Maillard, Arnold R. Kriegstein, Carl H. June, Howard Y. Chang, Avery D. Posey, Ansuman T. Satpathy

2020Cell461 citationsDOIOpen Access PDF

Topics & Concepts

CD19BiologyMural cellNeurotoxicityT cellCellCancer researchChimeric antigen receptorImmunologyAntigenCell biologyImmune systemMedicineEndothelial stem cellIn vitroInternal medicineToxicityBiochemistryGeneticsCAR-T cell therapy researchSingle-cell and spatial transcriptomicsNanowire Synthesis and Applications