Paired-pulse TMS and scalp EEG reveal systematic relationship between inhibitory GABA<sub>a</sub> signaling in M1 and fronto-central cortical activity during action stopping
Megan Hynd, Cheol Soh, Benjamin O. Rangel, Jan R. Wessel
Abstract
The neural mechanisms underlying rapid action stopping in humans are subject to intense debate, in part because recordings of neural signals purportedly reflecting inhibitory motor control are hard to directly relate to the true, physiological inhibition of motor cortex. For the first time, the current study combines EEG and transcranial magnetic stimulation (TMS) methods to demonstrate a direct correspondence between fronto-central control-related EEG activity following signals to cancel an action and the physiological inhibition of primary motor cortex.
Topics & Concepts
NeuroscienceStop signalInhibitory postsynaptic potentialTranscranial magnetic stimulationElectroencephalographyPsychologyContext (archaeology)NeurophysiologyPrimary motor cortexMotor cortexGABAergicStimulationBiologyComputer sciencePaleontologyLatency (audio)TelecommunicationsTranscranial Magnetic Stimulation StudiesEEG and Brain-Computer InterfacesNeural and Behavioral Psychology Studies