A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation
Bat-Chen Tamim-Yecheskel, Milana Fraiberg, Kamilya Kokabi, Saskia Freud, Oren Shatz, Letizia Marvaldi, Nemanja Subic, Ori Brenner, Michael Tsoory, Raya Eilam‐Altstadter, Inbal Biton, Alon Savidor, Nili Dezorella, Gali Heimer, Christian Behrends, Bruria Ben‐Zeev, Zvulun Elazar
Abstract
knockout mouse as a potential model for SPG49 and ascribe a new role to TECPR2 in macroautophagy/autophagy-related neurodegenerative disorders.
Topics & Concepts
BiologyKnockout mouseNeuroscienceLeukodystrophyBrainstemAutophagosomeSpinal cordAutophagyPathologyGeneticsDiseaseMedicineGeneApoptosisHereditary Neurological DisordersEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapy