Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters
Brandi N. Williamson, Joseph Prescott, José Luis Velasco Garrido, Raymond Alvarez, Heinz Feldmann, María Inés Barría
Abstract
Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
Topics & Concepts
VirologyMonoclonal antibodyAntibodyVirusSyrian hamstersBiologyHamsterImmunologyMedicineMolecular biologyViral Infections and VectorsVector-Borne Animal DiseasesViral Infections and Outbreaks Research