Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells
Aastha Kapoor, Carolyn Chen, Renato V. Iozzo
Abstract
vehicle-treated counterparts. Similar effects were obtained with the established cellular stress inducer tunicamycin. Notably, chronic exposure of aortic rings to endorepellin for 7-9 days markedly suppressed vessel sprouting, an angiostatic effect that was rescued by blocking PERK kinase activity. Our findings unravel a mechanism by which an extracellular matrix protein evokes stress signaling in endothelial cells, which leads to angiostasis.
Topics & Concepts
Cell biologyPhosphorylationPerlecanSignal transductionAngiogenesisUnfolded protein responseBiologyProteoglycanExtracellular matrixCancer researchEndoplasmic reticulumCell Adhesion Molecules ResearchProtease and Inhibitor MechanismsAngiogenesis and VEGF in Cancer