MSC secretome from amniotic fluid halts IL-1ß and TNF-a inflammation via the ERK/MAPK pathway, promoting cartilage regeneration in OA in vitro
Supatra Klaymook, Napatara Tirawanchai, Suparat Wichitwiengrat, Puttachart Chuaynarong, Sasiprapa Thongbopit, Keerati Chareancholvanich, Tatsanee Phermthai
Abstract
was restored in defective CPCs. In conclusion, this study demonstrated that AFS-se has therapeutic effects on OA by inhibiting the inflammatory functions of IL-1β and TNF-α through protein phosphorylation in the MAPK pathway while also promoting the regenerative and self-repair functions of CPCs in traumatized cartilage.
Topics & Concepts
MAPK/ERK pathwayCell biologyRegeneration (biology)InflammationCartilageAmniotic fluidTumor necrosis factor alphaIn vitroChemistryImmunologySignal transductionBiologyAnatomyPregnancyBiochemistryGeneticsFetusMesenchymal stem cell researchNeonatal Respiratory Health ResearchMicroRNA in disease regulation