Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice
Yingying He, John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Hui Jin, Xiaoqian Peng, Bo Ding, Chengheng Lin, Shengfeng Ji, Yanbing Ma, Weina Yang
Topics & Concepts
LRP1NeuroinflammationMicrogliaSignal transductionMAPK/ERK pathwayBiologyAstrogliosisGene silencingCell biologyTLR4GliosisNeuroscienceImmunologyInflammationLDL receptorEndocrinologyLipoproteinBiochemistryCholesterolGeneCentral nervous systemAlzheimer's disease research and treatmentsSignaling Pathways in DiseaseProtease and Inhibitor Mechanisms