Quinazolinone-dihydropyrano[3,2-b]pyran hybrids as new α-glucosidase inhibitors: Design, synthesis, enzymatic inhibition, docking study and prediction of pharmacokinetic
Maedeh Sherafati, Roghieh Mirzazadeh, Ebrahim Barzegari, Maryam Mohammadi‐Khanaposhtani, Homa Azizian, Mohammad Asgari, Samanesadat Hosseini, Ebrahim Zabihi, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Mohammad Mahdavi, Bagher Larijani, Hossein Rastegar, Haleh Hamedifar, Mir Hamed Hajimiri
Topics & Concepts
ChemistryAcarboseQuinazolinoneADMEIC50PyranDocking (animal)StereochemistryCytotoxicityEnzymeIn silicoPharmacophoreCombinatorial chemistryActive siteIn vitroBiochemistryPharmacologyMedicineGeneNursingQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity