Andexanet alfa in acute aortic syndrome: first UK experience
Nawwar Al‐Attar, Ahmed F Sedeek, Philip McCall, Jennifer Travers
Abstract
Andexanet alfa was employed to reverse the anticoagulant effect of direct oral anticoagulants in 3 patients who required emergent surgery for repair of type A aortic dissection. Its use was instrumental in securing haemostasis. However, we caution against the administration of Andexanet alfa prior to cardiopulmonary bypass as it can induce heparin resistance and complicate the perioperative monitoring of anticoagulation during cardiopulmonary bypass.
Topics & Concepts
Cardiopulmonary bypassMedicinePerioperativeHeparinAortic dissectionAnticoagulantAnesthesiaIntensive care medicineCardiologySurgeryAortaCardiac Arrest and ResuscitationAtrial Fibrillation Management and OutcomesCardiac, Anesthesia and Surgical Outcomes