Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery <i>via</i> SNARE-mediated membrane fusion
Ling Guo, Ye Zhang, Runxiu Wei, Xiaochen Zhang, Cuifeng Wang, Min Feng
Abstract
: Compared with other EV subtypes, MiV loaded with doxorubicin gain significant benefits in chemotherapeutic outcomes including survival rate improvements in metastatic ovarian cancer. Therefore, MiV represent a potent alterative to Exo and synthetic liposomes (Lipo) for tumor-targeting drug delivery.
Topics & Concepts
MicrovesiclesProinflammatory cytokineDoxorubicinCancer researchTropismDrug deliveryExosomeBiologyCell biologyChemistryInflammationImmunologymicroRNAChemotherapyBiochemistryOrganic chemistryGeneticsVirusGeneExtracellular vesicles in diseaseNanoplatforms for cancer theranosticsMicroRNA in disease regulation