Phomopsischalins A–C, polycyclic-fused cytochalasins from the endophytic fungus <i>Phomopsis</i> sp. shj2 and their abilities to induce lysosomal function
Rong Chen, Li-Jing Guo, Xue-Dan Li, Xing‐Ren Li, Kun Hu, Jian‐Wei Tang, Zhen-Nan Ye, Bing‐Chao Yan, Pema‐Tenzin Puno
Abstract
Phomopsischalins A−C (1–3), two classes of polycyclic-fused cytochalasins, were discovered from Phomopsis sp. shj2. Compound 2 is the first example of a cytochalasin accelerating lysosome function in a transcription factor EB-independent manner.
Topics & Concepts
ChemistryPhomopsisCytochalasinFungusCytochalasin DBotanyStereochemistryBiochemistryCytoskeletonBiologyCellMicrobial Natural Products and BiosynthesisPlant-Microbe Interactions and ImmunityPlant tissue culture and regeneration