Cyclic Ion Mobility–Collision Activation Experiments Elucidate Protein Behavior in the Gas Phase
Charles Eldrid, Aisha Ben-Younis, Jakub Ujma, Hannah M. Britt, Tristan Cragnolini, Symeon Kalfas, Dale A. Shepherd, Nick Tomczyk, Kevin Giles, Mike Morris, Rehana Akter, Daniel P. Raleigh, Konstantinos Thalassinos
Abstract
-MS data for hIAPP shows interconversion prior to dissociation, suggesting that the certain conformations have low energy barriers between them and transition between compact and extended forms.
Topics & Concepts
ChemistryTandem mass spectrometryCytochrome cMass spectrometryIon-mobility spectrometryIonTandemCollision-induced dissociationPeptideMyoglobinDissociation (chemistry)BiophysicsGas phaseMolecular dynamicsComputational chemistryChromatographyPhysical chemistryBiochemistryApoptosisComposite materialMaterials scienceOrganic chemistryBiologyMass Spectrometry Techniques and ApplicationsProtein Structure and DynamicsEnzyme Structure and Function