Autophagy in Human Diseases
Noboru Mizushima, Beth Levine
Abstract
Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Therapies aimed at regulating autophagy are being developed.
Topics & Concepts
AutophagyIntracellularMedicineOrganelleImmune systemCell biologyImmunologyBiologyApoptosisBiochemistryAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseEpigenetics and DNA Methylation