Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA
Marjorie Farrington, Jamie Elenz, Matthew L. Ginsberg, Charles Y. Chiu, Steve Miller, Scott Pangonis
Abstract
We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM and plaque reduction neutralization assays. Clinicians should recognize changing epidemiology of tickborne viruses to enhance encephalitis diagnosis and management.
Topics & Concepts
MetagenomicsVirologyBiologyEncephalitisVirusLineage (genetic)GeneticsGeneViral Infections and VectorsMosquito-borne diseases and controlVector-borne infectious diseases