Bioinspired nonheme iron complex that triggers mitochondrial apoptotic signalling pathway specifically for colorectal cancer cells
Yool Lee, Chaeun Oh, Jin Kim, Myong‐Suk Park, Woo Kyun Bae, Kyung Hyun Yoo, Seungwoo Hong
Abstract
resulted in (i) the activation and/or production of ROS species, (ii) the induction of intracellular impaired redox balance, and (iii) the promotion of the mitochondrial apoptotic signaling pathway in colorectal cancer cells. The results have implications for developing novel biomimetic complexes in cancer treatments and for designing potent candidates with cancer-specific antitumor activity.
Topics & Concepts
ApoptosisSignalling pathwaysColorectal cancerMitochondrionChemistrySignallingCell biologyCancerCancer researchHedgehog signaling pathwaySignal transductionBiologyBiochemistryGeneticsMetal-Catalyzed Oxygenation MechanismsMetal complexes synthesis and propertiesMagnetism in coordination complexes