MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways
Pengbo Lou, Xueyun Bi, Yuhua Tian, Guilin Li, Qianqian Kang, Cong Lv, Yongli Song, Jiuzhi Xu, Xiaole Sheng, Xu Yang, Ruiqi Liu, Qingyong Meng, Fazheng Ren, Maksim V. Plikus, Bin Liang, Bing Zhang, Huiyuan Guo, Zhengquan Yu
Abstract
Our findings identify miR-22 as a critical regulator in the control of thermogenesis in BAT and as a potential therapeutic target for human metabolic disorders.
Topics & Concepts
mTORC1ThermogenesisGlycolysisAdipocyteCell biologyBrown adipose tissueChemistrySignal transductionThermogeninBiologyAdipose tissueBiochemistryMetabolismPI3K/AKT/mTOR pathwayAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCancer, Hypoxia, and Metabolism