Mitochondria-mediated anti-proliferation of triple-negative breast cancer cells by Pd( <scp>ii</scp> )–, Pt( <scp>ii</scp> )–, and Au( <scp>iii</scp> )–NHC complexes of NCN pincers
Priyanka Sahu, Narayan Ch. Jana, Ananya Das, Nabanita Chatterjee, Katarzyna Gach, Joydev Dinda
Abstract
), activating pro-apoptotic proteins (BAX) and releasing cytochrome c. Additional studies revealed that the complexes were also potentially targeting thioredoxin reductase (TrxR) and possessed significant inhibitory effects. Among all tested compounds, complex 4 exhibited the highest inhibitory potential, which was also evidenced by molecular docking studies. The findings of the present investigation collectively emphasize the encouraging potential of the gold(III)-NHC pincer complex as a viable chemotherapeutic drug candidate for treating TNBC, supporting the need for additional research into its therapeutic potential.
Topics & Concepts
Triple-negative breast cancerChemistryMitochondrionMolecular biologyCancer researchBreast cancerCancerBiologyMedicineBiochemistryInternal medicineN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods