SARS-CoV-2 Immunohistochemistry In Placenta
Dinesh Rakheja, Kristina Treat, Charles F. Timmons, Deyssy Carrillo, Sara Miller, Edana Stroberg, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay
Abstract
Compared to the parental SARS-CoV-2 virus, infections by the now dominant Delta variant of SARS-CoV-2 appear to be more common and more severe in pregnant women. The need for a robust, cheap, and quick method for diagnosing placental infection by SARS-CoV-2 has thus become more acute. Here, we describe a highly sensitive and specific immunohistochemical assay for SARS-CoV-2 nucleocapsid protein for routine use in placental pathology practice.
Topics & Concepts
ImmunohistochemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PlacentaCoronavirus disease 2019 (COVID-19)VirologySars virus2019-20 coronavirus outbreakMedicinePathologyBiologyPregnancyFetusInfectious disease (medical specialty)DiseaseGeneticsOutbreakCOVID-19 Impact on ReproductionCOVID-19 and healthcare impactsReproductive System and Pregnancy