Transition metal–catalyzed remote C─H borylation: An emerging synthetic tool
Mirja Md Mahamudul Hassan, Saikat Guria, Sayan Dey, Jaitri Das, Buddhadeb Chattopadhyay
Abstract
Transition metal-catalyzed C─H bond activation and borylation is a powerful synthetic method that offers versatile synthetic transformation from organoboron compounds to virtually all other functional groups. Compared to the ortho-borylation, remote borylation remains more challenging owing to the inaccessibility of these C─H bonds. Enforcing the metal catalyst toward the remote C─H bonds needs well-judged catalyst design through proper ligand development. This review article aims to summarize the recent discoveries for the remote C─H borylation by the employment of new catalyst/ligand design with the help of steric of the ligand, noncovalent interactions. It has been found that C─H borylation now takes part in the total synthesis of natural products in a shorter route. Whereas, Ir-catalyzed C─H borylation is predominant, cobalt catalyst has also started to affect this field for sustainable and cost-effective development.