First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase
Xiaokang Li, Wenjing Qiu, Jinwen Li, Jinwen Li, Xi Chen, Yulu Hu, Ying Gao, Donglei Shi, Xinming Li, Huiling Lin, Zelan Hu, Guoqiang Dong, Chunquan Sheng, Bei Jiang, Conglong Xia, Chu‐Young Kim, Yuan Guo, Jian Li, Jian Li
Abstract
-β-gal-contaminated tissue sections of mice. Because of our probes, it was also discovered that SA-β-gal content in mice increased gradually with age and SA-β-gal accumulated most in the kidneys among the main organs of naturally aging mice, suggesting that the kidneys are the organs with the most severe aging during natural aging.
Topics & Concepts
FluorescenceSenescenceFluorescence-lifetime imaging microscopyLive cell imagingChemistryBiophysicsBiochemistryBiologyCell biologyOpticsCellPhysicsAdvanced biosensing and bioanalysis techniquesAdvanced Nanomaterials in CatalysisMolecular Sensors and Ion Detection