Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis
Xuejiao Chen, Wenfeng Hua, Xin Huang, Yu‐Ming Chen, Junxian Zhang, Guowei Li
Abstract
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone structure is destroyed to the degree that bone becomes fragile and prone to fractures. Emerging evidence suggests that N6-methyladenosine (m6A) modification, a novel epitranscriptomic marker, has a significant role in bone development and metabolism. In this review, we summarize the most up-to-date evidence of m6A RNA modification in osteoporosis and highlight the potential role of m6A in prevention, treatment and management of osteoporosis.
Topics & Concepts
OsteoporosisN6-MethyladenosineBone remodelingRNABioinformaticsMedicineBone massBiologyInternal medicineBiochemistryGeneMethyltransferaseMethylationRNA modifications and cancerRNA Research and SplicingCancer-related gene regulation