Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients
Marzia Ognibene, Martina Morini, Alberto Garaventa, Marina Podestà, Annalisa Pezzolo
Abstract
genes may be responsible for poor prognosis of HR-NB tumors with 6q27 loss, and their haploinsufficiency may be crucial in accelerating tumor progression.
Topics & Concepts
HaploinsufficiencyBiologyGeneChromosomeNeuroblastomaPhenotypeShort statureCancer researchSuppressorTumor suppressor geneInternal medicineOncologyGeneticsMedicineEndocrinologyCarcinogenesisCell cultureNeuroblastoma Research and TreatmentsNeuroendocrine Tumor Research AdvancesCancer, Hypoxia, and Metabolism