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SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway

Jinyu Piao, Zhuoxuan Su, Jiqian He, Tianxin Zhu, Faxin Fan, Xin Wang, Zhenzhen Yang, Huixia Zhan, Duosheng Luo

2024Cellular Signalling13 citationsDOI

Topics & Concepts

RHOACell biologyIn vivoLimitingFunction (biology)In vitroSphingosine kinase 1Barrier functionBiologyChemistrySignal transductionBiochemistrySphingosineReceptorSphingosine-1-phosphateGeneticsMechanical engineeringEngineeringSphingolipid Metabolism and SignalingProtein Kinase Regulation and GTPase SignalingProtease and Inhibitor Mechanisms
SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway | Litcius