Synthesis of α-Aminosilanes by 1,2-Metalate Rearrangement Deoxygenative Silylation of Aromatic Amides
Zhou Lü, Jian Qiu, Cece Wang, Feng Zhang, Kai Yang, Qiuling Song
Abstract
An efficient nickel-catalyzed deoxygenative silylation reaction of aromatic amides with silylboranes in the presence of a Sm/SmI2 system for the construction of α-aminosilanes is described. This strategy provides a direct method for synthesizing α-aminosilanes with high efficiency and good functional group compatibility and includes readily accessible starting materials and valuable products.
Topics & Concepts
ChemistrySilylationCompatibility (geochemistry)CatalysisCombinatorial chemistryOrganic chemistryChemical engineeringEngineeringOrganoboron and organosilicon chemistryAdvanced Synthetic Organic ChemistrySynthetic Organic Chemistry Methods