Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML
Yuki Nishida, Ran Zhao, Lauren Heese, Hiroki Akiyama, S. Patel, Alex M. Jaeger, Rodrigo Jácamo, Kensuke Kojima, Man Chun John, Vivian Ruvolo, Dhruv Chachad, William G. Devine, Susan Lindquist, R. Eric Davis, John A. Porco, Luke Whitesell, Michael Andreeff, Jo Ishizawa
Topics & Concepts
HSF1BiologyCancer researchMyeloid leukemiaLeukemiaeIF4AInitiation factorGene knockdownEukaryotic initiation factorCell cultureHeat shock proteinTranslation (biology)Hsp70GeneticsMessenger RNAGeneAcute Myeloid Leukemia ResearchProtein Degradation and InhibitorsCancer-related gene regulation