Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
Simona Musella, Lidia Carotenuto, Nunzio Iraci, Giulia Baroli, Tania Ciaglia, Piera Nappi, Manuela Giovanna Basilicata, Emanuela Salviati, Vincenzo Barrese, Vincenzo Vestuto, Giuseppe Pignataro, Giacomo Pepe, Eduardo Sommella, Veronica Di Sarno, Michele Manfra, Pietro Campiglia, Isabel Gómez‐Monterrey, Alessia Bertamino, Maurizio Taglialatela, Carmine Ostacolo, Francesco Miceli
Abstract
as a promising lead compound for the development of novel Kv7 activators for the treatment of hyperexcitability diseases.
Topics & Concepts
AnticonvulsantChemistryActivator (genetics)PharmacologyEpilepsyLead compoundIn vitroNeuroscienceReceptorBiochemistryMedicinePsychologyIon channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias