Construction of C2-Quaternary-indol-3-ones via Rh<sup>III</sup>-Catalyzed [3+2] Spirocyclization from Indole Ketones and Nitroolefins
Wen-Bi Hu, Yanqing Qiu, Wen‐Yi Wei, Qing Li, Yan‐Jun Xu
Abstract
Novel complex C2-quaternary-indol-3-one units bearing versatile nitro groups have been successfully developed from pseudo-indolones and α,β-unsaturated nitroolefins through rhodium-catalyzed C-H activation/[3 + 2] spirocyclization. Notably, four diastereomers could be selectively obtained in the reaction by condition control.
Topics & Concepts
Indole testCatalysisChemistryQuaternaryMedicinal chemistryStereochemistryOrganic chemistryBiologyPaleontologyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions