Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides
Niels R. M. Reintjens, Elena Tondini, Ana R. de Jong, Nico J. Meeuwenoord, Fabrizio Chiodo, Evert Peterse, Herman S. Overkleeft, Dmitri V. Filippov, Gijsbert A. van der Marel, Ferry Ossendorp, Jeroen D. C. Codée
Abstract
. Synthetic TLR4 ligands thus show great promise in potentiating the conjugate vaccine platform for application in cancer vaccination.
Topics & Concepts
ChemistryConjugatePeptideAntigenLinkerLigand (biochemistry)Cancer immunotherapyImmune systemImmunotherapyIn vivoLipopeptideReceptorBiochemistryImmunologyBiologyOperating systemBiotechnologyComputer scienceMathematical analysisMathematicsGeneticsBacteriaImmune Response and InflammationImmunotherapy and Immune ResponsesAntimicrobial Peptides and Activities