Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Richard Karlsson, Pradeep Chopra, Apoorva Joshi, Zhang Yang, Sergey Y. Vakhrushev, Thomas Mandel Clausen, Chelsea D. Painter, Gergő Péter Szekeres, Yen‐Hsi Chen, Daniel R. Sandoval, Lars Hestbjerg Hansen, Jeffrey D. Esko, Kevin Pagel, Douglas P. Dyer, Jeremy E. Turnbull, Henrik Clausen, Geert‐Jan Boons, Rebecca L. Miller
Abstract
-sulfate structure-function and demonstrate proof of concept for tailored cell-based synthesis of next-generation heparins.
Topics & Concepts
SulfationHeparinHeparan sulfateFunction (biology)GlycosaminoglycanChemistryComputational biologyBiochemistryCell biologyBiologyProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis