Total syntheses of<i>Ganoderma</i>-derived meroterpenoids, (−)-oregonensin A, (−)-chizhine E, (−)-applanatumol U, and (−)-<i>ent</i>-fornicin A
Kazuki Hori, Shogo Kamo, Kazuyuki Sugita
Abstract
Total syntheses of four Ganoderma -derived meroterpenoids have been achieved with the longest linear sequence of 6–8 steps and in 21–36% overall yield by using reductive lactonization, alkylation, and sulfoxide-β- syn -elimination as key steps.
Topics & Concepts
ChemistryEnantioselective synthesisStereochemistryButenolideTotal synthesisYield (engineering)AlkylationArylAlkylOrganic chemistryCatalysisMetallurgyMaterials scienceFungal Biology and ApplicationsSesquiterpenes and Asteraceae StudiesPhytochemistry and Bioactivity Studies