Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites
Manish Goyal, Adina Heinberg, Vera Mitesser, Sofiya Kandelis-Shalev, Brajesh K. Singh, Ron Dzikowski
Abstract
Plasmodium falciparum is the deadliest human parasite that causes malaria when it reaches the bloodstream and begins proliferating inside red blood cells, where the parasites are particularly prone to DNA damage. The molecular mechanisms that allow these pathogens to maintain their genome integrity under such conditions are also the driving force for acquiring genome plasticity that enables them to create antigenic variation and become resistant to essentially all available drugs.
Topics & Concepts
MalariaBiologyGenomePlasmodium falciparumHistoneAntigenic variationEpigeneticsDNAPlasmodium (life cycle)GeneticsParasite hostingVirologyEvolutionary biologyAntigenGeneImmunologyComputer scienceWorld Wide WebDNA Repair MechanismsMalaria Research and ControlHIV Research and Treatment