Quercetin and Heart Health: From Molecular Pathways to Clinical Findings
Fereshteh Nazari‐Khanamiri, Morteza Ghasemnejad‐Berenji
Abstract
Cardiovascular diseases (CVD) are the leading causes of global death, increasing over time. Despite current novel improvements, it is still a major medical challenge. Quercetin (QU) is a flavonoid with anti-inflammatory, vasodilatory, antihypertensive, antiarrhythmogenic, and antiapoptotic effects. It can reduce low-density lipoprotein (LDL) and cholesterol oxidation and prevent endothelial dysfunction in CVD. Also, it can protect myocardial cells against oxidative stress and inflammation caused by free radicals. An updated review of the literature on the cardiovascular effects of quercetin was performed using PubMed, Embase, and Science Direct databases. The aim of this review is to summarize the various effects of quercetin on the cardiovascular system.