Rhodium( <scp>i</scp> )-catalyzed cascade C(sp <sup>2</sup> )–H bond alkylation – amidation of anilines: phosphorus as traceless directing group
Marie Peng, Denis Ari, Thierry Roisnel, Henri Doucet, Jean‐François Soulé
Abstract
)-H bond activation prior to N-P bond hydrolysis, streamlining one-pot intramolecular amidation. Moreover, we demonstrate the applicability of this reaction by synthesizing an antipsychotic drug. Detailed mechanistic investigations revealed the involvement of a Rh-H intermediate, with substrate inhibition through catalyst saturation.
Topics & Concepts
ChemistryIntramolecular forceCatalysisRhodiumAnilineHydrolysisAlkylationCombinatorial chemistrySubstrate (aquarium)TautomerMedicinal chemistryStereochemistryOrganic chemistryOceanographyGeologyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions