Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress
Xiumin Zhang, Mahwish Shaukat, Ronggang Liu, Liyang Peng, Yuxiao Wang, Wentao Su, Yukun Song, Mingqian Tan
Abstract
pharmacokinetic experiments revealed that AXT@TPP-WPI-GOS could enhance AXT utilization by 28.18 ± 11.69%. Fluorescence imaging in mice demonstrated significantly higher levels of AXT@TPP-WPI-GOS accumulation in the liver compared to that of free AXT. Therefore, these nanoparticles hold promising applications in nutrient fortification, improving the bioavailability of AXT and supporting hepatic well-being.
Topics & Concepts
AstaxanthinOxidative stressHepatocytePharmacologyChemistryMedicineBiochemistryCarotenoidIn vitroBiochemical effects in animalsAntioxidant Activity and Oxidative StressSelenium in Biological Systems