Tailoring of the axon initial segment shapes the conversion of synaptic inputs into spiking output in OFF-α T retinal ganglion cells
Paul Werginz, Vineeth Raghuram, Shelley I. Fried
Abstract
1.6 channels in longer AISs directly mediates higher rates of spiking and helps avoid depolarization block that terminates spiking in ventral cells with shorter AISs. The pre- and postsynaptic specializations that shape the output of OFF-α T RGCs interact in different ways: In dorsal cells, strong inputs and the long AISs are both necessary to generate their strong, sustained spiking outputs, while in ventral cells, weak inputs or the short AISs are both sufficient to limit the spiking signal.
Topics & Concepts
NeuroscienceExcitatory postsynaptic potentialPostsynaptic potentialRetinaRetinal wavesAxonBiologyAnatomyDepolarizationRetinal ganglion cellGiant retinal ganglion cellsInhibitory postsynaptic potentialBiophysicsReceptorBiochemistryRetinal Development and DisordersNeuroscience and Neural EngineeringPhotoreceptor and optogenetics research