Tale of the Breslow intermediate, a central player in N-heterocyclic carbene organocatalysis: then and now
Monika Pareek, Yernaidu Reddi, Raghavan B. Sunoj
Abstract
detection, isolation, and characterization of the Breslow intermediate are scattered over a series of reports spanning well over a decade, and we intend to consolidate them in this review and provide a critical assessment of these developments. Given the central role of the Breslow intermediate in organocatalytic reactions, this treatise is expected to serve as a valuable source of knowledge on the same.
Topics & Concepts
CarbeneOrganocatalysisCatalysisChemistryIsolation (microbiology)Combinatorial chemistryStereochemistryOrganic chemistryEnantioselective synthesisBiologyBioinformaticsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods