Comprehensive characterization of functional eRNAs in lung adenocarcinoma reveals novel regulators and a prognosis-related molecular subtype
Na Qin, Zijian Ma, Cheng Wang, Erbao Zhang, Yuancheng Li, Mingtao Huang, Congcong Chen, Chang Zhang, Jingyi Fan, Yayun Gu, Xianfeng Xu, Yang Liu, Xiaoxia Wei, Rong Yin, Yue Jiang, Juncheng Dai, Guangfu Jin, Lin Xu, Zhibin Hu, Hongbing Shen, Hongxia Ma
Abstract
The genome-wide identification and characterization of eRNAs reveal novel regulators for the development of lung cancer, which provides a new biological dimension for the understanding of eRNAs during lung carcinogenesis and emphasize the clinical utility of eRNA-based molecular subtypes in the treatment of lung adenocarcinoma.
Topics & Concepts
CarcinogenesisAdenocarcinomaBiologyGeneEnhancerEnhancer RNAsCancer researchComputational biologyGene expressionGeneticsCancerCancer-related molecular mechanisms researchRNA modifications and cancerGenomics and Chromatin Dynamics