Superiority of an Asymmetric Perylene Diimide in Terms of Hydrosolubility, G-Quadruplex Binding, Cellular Uptake, and Telomerase Inhibition in Prostate Cancer Cells
Ratasark Summart, Pak Thaichana, Jutharat Supan, Puttinan Meepowpan, T. Randall Lee, Wirote Tuntiwechapikul
Abstract
-ethyl piperidine side chain of PDI is sufficient for G-quadruplex binding, while another side chain can be tuned to elicit desirable properties. These findings might lead to better PDIs for use as anticancer drugs.
Topics & Concepts
TelomeraseChemistryTelomereG-quadruplexPerylenePiperSide chainDNACancer cellCancerBiochemistryBiologyGeneGeneticsPaleontologyPolymerOrganic chemistryMoleculeDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery