Cascaded bio-responsive delivery of eNOS gene and ZNF<sub>580</sub> gene to collaboratively treat hindlimb ischemia <i>via</i> pro-angiogenesis and anti-inflammation
Xiaoyu Wang, Bin Su, Bin Gao, Jiaying Zhou, Xiang‐Kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Yakai Feng
Abstract
The cascaded, bio-responsively delivered eNOS gene and ZNF<sub>580</sub> gene overcome transfection bottlenecks and collaboratively exert anti-ischemic function <italic>via</italic> promoting angiogenesis and alleviating inflammation.
Topics & Concepts
AngiogenesisInflammationEnosGeneTransfectionGene deliveryGenetic enhancementIschemiaHindlimbFunction (biology)BiologyCancer researchCell biologyBioinformaticsMedicineImmunologyGeneticsInternal medicineNitric oxideEndocrinologyNitric oxide synthaseRNA Interference and Gene DeliveryMicroRNA in disease regulationAdvanced biosensing and bioanalysis techniques