Photoredox-Catalyzed and Silane-Mediated Hydrofluoromethylation of Unactivated Alkenes with Fluoroiodomethane in Water
Chenchen Hu, Chao‐Lai Tong, Yuyang Zhang, Xiu‐Hua Xu, Feng‐Ling Qing
Abstract
The first hydrofluoromethylation of unactivated alkenes with fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH 2 F radical toward unactivated alkenes.
Topics & Concepts
ChemistrySilaneCatalysisSolventOrganic chemistryPhotochemistryCombinatorial chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds