Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life
Nadja A. Vielot, Amanda Brinkman, Christina R. DeMaso, Samuel Vilchez, Lisa C. Lindesmith, Filemón Bucardo, Yaoska Reyes, Ralph S. Baric, Elizabeth P. Ryan, Ralph P. Braun, Sylvia Becker‐Dreps
Abstract
We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.
Topics & Concepts
NorovirusMedicineVirologyAntibodyComputational biologyImmunologyVirusBiologyViral gastroenteritis research and epidemiologyVirus-based gene therapy researchRespiratory viral infections research