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TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway

Min-Yao Liu, Hongmin Li, Xinyu Wang, Xia Ran, Xiang Li, Yu-Jie Ma, Miao Wang, Hong-Sheng Zhang

2022Free Radical Biology and Medicine102 citationsDOI

Topics & Concepts

Gene knockdownCancer researchLipid peroxidationAMPKChemistryMalondialdehydeCancer cellProgrammed cell deathGPX4Reactive oxygen speciesCell biologyColorectal cancerCancerApoptosisOxidative stressBiologyKinaseBiochemistryProtein kinase ASuperoxide dismutaseGeneticsGlutathione peroxidaseFerroptosis and cancer prognosisCancer-related molecular mechanisms researchCancer, Lipids, and Metabolism
TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway | Litcius