Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans
Zhe Zhang, Bo‐Sheng Zhang, Kaili Li, Yang An, Ce Liu, Xue‐Ya Gou, Yong‐Min Liang
Abstract
This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.
Topics & Concepts
AminationBenzofuranIndolineChemistryPalladiumCatalysisCascade reactionFunctional groupCombinatorial chemistryOrganic chemistrySubstrate (aquarium)GeologyOceanographyPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions