Cytotoxicity of Donor Natural Killer Cells to Allo-Reactive T Cells Are Related With Acute Graft-vs.-Host-Disease Following Allogeneic Stem Cell Transplantation
Lixia Sheng, Qitian Mu, Xiaoqing Wu, Shujun Yang, Huiling Zhu, Jiaping Wang, Yanli Lai, Hao Wu, Ye Sun, Yongxian Hu, Huarui Fu, Yi Wang, Kaihong Xu, Yongcheng Sun, Yanli Zhang, Ping Zhang, Miao Zhou, Binbin Lai, Zhijuan Xu, Minjie Gao, Yi Zhang, Guifang Ouyang
Abstract
These findings reveal that the degranulation activity of NK in allografts toward allo-activated T cells was associated with the occurrence and the severity of aGVHD, after allogeneic stem cell transplantation. This suggested that cytotoxicity of donor NK cells to allo-reactive T cells have important roles in aGVHD regulation.
Topics & Concepts
Graft-versus-host diseaseCytotoxicityStem cellTransplantationImmunologyMedicineBiologyIn vitroCell biologySurgeryBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation