Copper-catalyzed amino radical tandem cyclization toward the synthesis of indolo-[2,1-<i>a</i>]isoquinolines
Meiling Liu, Jingling Wang, Xuesong Li, Wenhui Sun, Xue‐Yuan Liu
Abstract
We report a convenient process for synthesizing indolo-[2,1- a ]isoquinoline tetracyclic skeletons in one pot via a low-cost copper-catalyzed tandem amino radical cyclization, in which one C–C bond and one C–N bond are synchronously established.
Topics & Concepts
ChemistryIsoquinolineTandemRadical cyclizationCatalysisCopperCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryComposite materialMaterials scienceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques