Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome
Hannah A. Ledford, Lu Ren, Phung N. Thai, Seojin Park, Valeriy Timofeyev, Padmini Sirish, Wilson Xu, Aiyana M. Emigh, James R. Priest, Marco Pérez, Euan A. Ashley, Vladimir Yarov‐Yarovoy, Ebenezer N. Yamoah, Xiao-Dong Zhang, Nipavan Chiamvimonvat
Topics & Concepts
hERGLong QT syndromeInduced pluripotent stem cellUbiquitin ligaseHEK 293 cellsCell biologyMedicinePotassium channelUbiquitinIon channelCardiac action potentialMutationProtein subunitProtein degradationPatch clampBiologyElectrophysiologyGeneticsGeneInternal medicineQT intervalEmbryonic stem cellRepolarizationReceptorCardiac electrophysiology and arrhythmiasIon channel regulation and functionCardiac Arrhythmias and Treatments