Elevated exercise blood pressure in middle-aged women is associated with altered left ventricular and vascular stiffness
Satyam Sarma, Erin J. Howden, Graeme Carrick‐Ranson, Justin S. Lawley, Christopher M. Hearon, Mitchel Samels, Braden Everding, Sheryl Livingston, Beverley Adams‐Huet, M. Dean Palmer, Benjamin D. Levine
Abstract
Women are at increased risk for heart failure with preserved ejection fraction (HFpEF) largely due to higher prevalence of arterial and cardiac stiffening. We were able to identify several subclinical markers of early (stages A and B) HFpEF pathophysiology largely on the basis of exercise blood pressure (BP) response in otherwise healthy middle-aged women. Exercise BP response may be an inexpensive screening tool to identify women at highest risk for developing future HFpEF.
Topics & Concepts
Subclinical infectionCardiologyMedicineInternal medicineArterial stiffnessHeart failure with preserved ejection fractionBlood pressureHeart failureEjection fractionPathophysiologyCardiovascular Health and Disease PreventionHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology