Narrative Review of the Relationship Between CKD and Diabetic Foot Ulcer

Abstract

Diabetic foot ulcer (DFU) and chronic kidney disease (CKD) are 2 significant complications of diabetes mellitus (DM). Up to 40% of patients with DM are expected to also develop CKD, and 19% to 34% will suffer from DFU during their lifetimes. However, data on and of are of on Diabetic to to of DFU and also to to of CKD, with patients with disease of foot also patients with patients to DFU and DFU of of of disease and also to of 2 on and DFU and and foot and DFU and and DFU on 2 to of Diabetic foot ulcer (DFU) and chronic kidney disease (CKD) are 2 significant complications of diabetes mellitus (DM). Up to 40% of patients with DM are expected to also develop CKD, and 19% to 34% will suffer from DFU during their lifetimes. However, data on and of are of on Diabetic to to of DFU and also to to of CKD, with patients with disease of foot also patients with patients to DFU and DFU of of of disease and also to of 2 on and DFU and and foot and DFU and and DFU on 2 to of DM chronic and of and to of Diabetic foot and their Diabetic foot of of foot and with with complications to of foot of to of with and 19% to 34% of patients with diabetes will suffer from foot ulcer during their Diabetic foot and their diabetes of patients with diabetes of and with to patients with and and of patients with of and significant on of DFU to of patients with diabetes to of DFU foot of on Diabetic of disease disease of foot 2 of foot and of foot ulcer and with and and to foot and and patients with diabetes with on and of foot disease with of foot ulcer on of patients with diabetes of DFU with patients with and and to foot and and and and DFU and of to on and and with and are and to diabetes of foot ulcer patients with of patients and disease to of with foot and on and and of of foot patients and their patients with on patients with and on of DFU with to on DFU on to of on patients of of and and patients to of and with and DM with of of patients with disease patients with and chronic and and of from and of patients with disease patients with chronic kidney and and and and are of and of patients diabetes and of with of and and of with patients from and and and foot ulcer patients with to and and are to of DFU patients with of patients on and to of with of DFU with of foot and of diabetes foot patients with diabetes and chronic kidney of foot kidney disease and foot diabetes of on patients with of and of to during with of with diabetes DFU and to of to of and foot to of and and to with of of of patients with chronic kidney of and of to of and chronic patients with diabetes to patients diabetes of and of and foot and DFU of foot and with and and of and of of chronic kidney and and and chronic kidney of and and to to patients with foot complications and patients with 2 diabetes mellitus and chronic kidney disease to of with and of of chronic and to and kidney to foot of with and patients and their on of and with chronic kidney disease with diabetes during Diabetic foot disease with and on foot patients foot foot with to 40% of patients with diabetes are expected to also develop of and of chronic kidney disease patients with 2 to data from of and of kidney with are 2 to and to kidney patients with of of complications of with and on and of are foot of foot of during with and and with and of foot and of foot of with of patients with patients also and 2 diabetes mellitus and chronic kidney However, of DFU to of of and of of and of and of and CKD, and to to of and foot patients with diabetes and chronic kidney of foot and of patients on 2 and to to of However, of and of of chronic kidney disease and with foot and of patients with with to and of chronic kidney disease and with foot and significant foot of foot of patients with diabetes foot and DFU patients with 2 foot and and 2 diabetes mellitus and DFU with of from patients with diabetes to to with foot and and 2 diabetes mellitus with DFU and of foot and with disease on and DM of with of of and foot of patients of with DFU with diabetes and of foot to also to of ulcer foot with disease on with patients with kidney disease and foot diabetes and with foot and and 2 diabetes mellitus and foot and on and from and with their of foot and on from to with patients with and with patients with DFU and with foot and foot and and foot and However, to with to of foot of 2 foot to with of DFU on their of of foot and with disease on and DM of with on with data from and to and foot and of diabetes of patients and to disease of 2 of and 2 also to DFU of patients with diabetes foot and patients with foot of from of of DFU of and are with patients with and of patients foot their of foot and on from to with patients with with foot and foot and with foot and and of foot patients and their DFU of foot of patients and and also of of of disease and significant and of from to of and to patients with diabetes and with of and and from to and from to on from to of disease and and to to and and and to data of and foot ulcer patients with their of patients with diabetes with foot and and from to data of of of and of and with patients and of foot patients with diabetes on with to DFU of patients on on of and of foot with from to of foot patients with diabetes on with to to kidney of and of foot of of patients with and diabetes and on to of to of of and to However, foot patients and patients Diabetic and are to DFU and are of foot of and of to with and during to diabetes to from to of of to and and of of to and foot of and with foot of to of patients are on with of and patients with to with and chronic of on are and will to of and of to on and of DFU and to to of chronic However, foot and to of data and of patients from to with of to of of foot ulcer on chronic and are with of foot and DM chronic and of and to of Diabetic foot and their Diabetic foot of of foot and with with complications to of foot of to of with and 19% to 34% of patients with diabetes will suffer from foot ulcer during their Diabetic foot and their diabetes of patients with diabetes of and with to patients with and and of patients with of and significant on of DFU to of patients with diabetes to of DFU foot of on Diabetic of disease disease of foot 2 of foot and of foot ulcer and with and and to foot and and patients with diabetes with on and of foot disease with of foot ulcer on of patients with diabetes of DFU with patients with and and to foot and and and and DFU and of to on and and with and are and to diabetes of foot ulcer patients with of patients and disease to of with foot and on and and of of foot patients and their patients with on patients with and on of DFU with to on DFU on to of on patients of of and and patients to of and with and DM with of of patients with disease patients with and chronic and and of from and of patients with disease patients with chronic kidney and and and and are of and of patients diabetes and of with of and and of with patients from and and and foot ulcer patients with to and and are to of DFU patients with of patients on and to of with of DFU with of foot and of diabetes foot patients with diabetes and chronic kidney of foot kidney disease and foot diabetes of on patients with of and of to during with of with diabetes DFU and to of to of and foot to of and and to with of of of patients with chronic kidney of and of to of and chronic patients with diabetes to patients diabetes of and of and foot and DFU of foot and with and and of and of of chronic kidney and and and chronic kidney of and and to to patients with foot complications and patients with 2 diabetes mellitus and chronic kidney disease to of with and of of chronic and to and kidney to foot of with and patients and their on of and with chronic kidney disease with diabetes during Diabetic foot disease with and on foot patients foot foot with to 40% of patients with diabetes are expected to also develop of and of chronic kidney disease patients with 2 to data from of and of kidney with are 2 to and to kidney patients with of of complications of with and on and of are foot of foot of during with and and with and of foot and of foot of with of patients with patients also and 2 diabetes mellitus and chronic kidney However, of DFU to of of and of of and of and of and CKD, and to to of and foot patients with diabetes and chronic kidney of foot and of patients on 2 and to to of However, of and of of chronic kidney disease and with foot and of patients with with to and of chronic kidney disease and with foot and significant foot of foot of patients with diabetes foot and DFU patients with 2 foot and and 2 diabetes mellitus and DFU with of from patients with diabetes to to with foot and and 2 diabetes mellitus with DFU and of foot and with disease on and DM of with of of and foot of patients of with DFU with diabetes and of foot to also to of ulcer foot with disease on with patients with kidney disease and foot diabetes and with foot and and 2 diabetes mellitus and foot and on and from and with their of foot and on from to with patients with and with patients with DFU and with foot and foot and and foot and However, to with to of foot of 2 foot to with of DFU on their of of foot and with disease on and DM of with on with data from and to and foot and of diabetes of patients and to disease of 2 of and 2 also to DFU of patients with diabetes foot and patients with foot of from of of DFU of and are with patients with and of patients foot their of foot and on from to with patients with with foot and foot and with foot and and of foot patients and their DFU of foot of patients and and also of of of disease and significant and of from to of and to patients with diabetes and with of and and from to and from to on from to of disease and and to to and and and to data of and foot ulcer patients with their of patients with diabetes with foot and and from to data of of of and of and with patients and of foot patients with diabetes on with to DFU of patients on on of and of foot with from to of foot patients with diabetes on with to to kidney of and of foot of of patients with and diabetes and on to of to of of and to However, foot patients and patients Diabetic and are to DFU and are of foot of and of to with and during to diabetes to from to of of to and and of of to and foot of and with foot of to of patients are on with of and patients with to with and chronic of on are and will to of and of to on and of DFU and to to of chronic However, foot and to of data and of patients from to with of to of of foot ulcer on chronic and are with of foot and and to diabetes of foot ulcer patients with of patients and disease to of with foot and on and and of of foot patients and their patients with on patients with and on of DFU with to on DFU on to of on patients of of and and patients to of and with and DM with of of patients with disease patients with and chronic and and of from and of patients with disease patients with chronic kidney and and and and are of and of patients diabetes and of with of and and of with patients from and and and foot ulcer patients with to and and are to of DFU patients with of patients on and to of with of DFU with of foot and of diabetes foot patients with diabetes and chronic kidney of foot kidney disease and foot diabetes of on patients with of and of to during with of with diabetes DFU and to of to of and foot to of and and to with of of of patients with chronic kidney of and of to of and chronic patients with diabetes to patients diabetes of and of and foot and DFU of foot and with and and of and of of chronic kidney and and and chronic kidney of and and to to patients with foot complications and patients with 2 diabetes mellitus and chronic kidney disease to of with and of of chronic and to and kidney to foot of with and patients and their on of and with chronic kidney disease with diabetes during Diabetic foot disease with and on foot patients foot foot with to diabetes of foot ulcer patients with of patients and disease to of with foot and on and and of of foot patients and their patients with on patients with and on of DFU with to on DFU on to of on patients of of and and patients to of and with and DM with of of patients with disease patients with and chronic and and of from and of patients with disease patients with chronic kidney and and and and are of and of patients diabetes and of with of and and of with patients from and and and foot ulcer patients with to and and are to of DFU patients with of patients on and to of with of DFU with of foot and of diabetes foot patients with diabetes and chronic kidney of foot kidney disease and foot diabetes of on patients with of and of to during with of with diabetes and of of foot patients and their patients with on patients with and on of DFU with to on DFU on to of on patients of of and and patients to of and with and DM with of of patients with disease patients with and chronic and and of from and of patients with disease patients with chronic kidney and and and and are of and of patients diabetes and of with of and and of with patients from and and and foot ulcer patients with to and and are to of DFU patients with of patients on and to of with of DFU with of foot and of diabetes foot patients with diabetes and chronic kidney of foot kidney disease and foot diabetes of on patients with of and of to during with of with diabetes DFU and to of to of and foot to of and and to with of of of patients with chronic kidney of and of to of and chronic patients with diabetes to patients diabetes of DFU and to of to of and foot to of and and to with of of of patients with chronic kidney of and of to of and chronic patients with diabetes to patients diabetes of and of and foot and DFU of foot and with and and of and of of chronic kidney and and and chronic kidney of and and to to patients with foot complications and patients with 2 diabetes mellitus and chronic kidney disease However, of and foot and DFU of foot and with and and of and of of chronic kidney and and and chronic kidney of and and to to patients with foot complications and patients with 2 diabetes mellitus and chronic kidney disease to of with and of of chronic and to and kidney to foot of with and patients and their on of and with chronic kidney disease with diabetes during Diabetic foot disease with and on foot patients foot foot with to of with and of of chronic and to and kidney to foot of with and patients and their on of and with chronic kidney disease with diabetes during Diabetic foot disease with and on foot patients foot foot with to 40% of patients with diabetes are expected to also develop of and of chronic kidney disease patients with 2 to data from of and of kidney with are 2 to and to kidney patients with of of complications of with and Up to 40% of patients with diabetes are expected to also develop of and of chronic kidney disease patients with 2 to data from of and of kidney with are 2 to and to kidney patients with of of complications of with and on and of are foot of foot of during with and and with and of foot and of foot of with of patients with patients also and 2 diabetes mellitus and chronic kidney However, of DFU to of of and of of and of and of and CKD, and to to of and foot patients with diabetes and chronic kidney of foot and of patients on 2 and to to of However, of and of of chronic kidney disease and with foot and of patients with with to and of chronic kidney disease and with foot and significant foot of foot on and of are foot of foot of during with and and with and of foot and of foot of with of patients with patients also and 2 diabetes mellitus and chronic kidney However, of DFU to of of and of of and of and of and CKD, and to to of and foot patients with diabetes and chronic kidney of foot and of patients on 2 and to to of However, of and of of chronic kidney disease and with foot and of patients with with to and of chronic kidney disease and with foot and significant foot of foot DFU of patients with diabetes foot and DFU patients with 2 foot and and 2 diabetes mellitus and DFU with of from patients with diabetes to to with foot and and 2 diabetes mellitus with DFU and of foot and with disease on and DM of with of of and foot of patients of with DFU with diabetes and of foot to also to of ulcer foot with disease on of patients with diabetes foot and DFU patients with 2 foot and and 2 diabetes mellitus and DFU with of from patients with diabetes to to with foot and and 2 diabetes mellitus with DFU and of foot and with disease on and DM of with of of and foot of patients of with DFU with diabetes and of foot to also to of ulcer foot with disease on DFU with patients with kidney disease and foot diabetes and with foot and and 2 diabetes mellitus and foot and on and from and with their of foot and on from to with patients with and with patients with DFU and with foot and foot and and foot and However, to with to of foot of 2 foot to with of DFU on their of of foot and with disease on and DM of with on with data from and to and foot and of diabetes of patients and to disease of 2 of and 2 also to DFU of patients with diabetes foot and patients with foot of from of of DFU of and are with patients with and of patients foot their of foot and on from to with patients with with foot and foot and with foot and and of foot patients and their with patients with kidney disease and foot diabetes and with foot and and 2 diabetes mellitus and foot and on and from and with their of foot and on from to with patients with and with patients with DFU and with foot and foot and and foot and However, to with to of foot of 2 foot to with of DFU on their of of foot and with disease on and DM of with on with data from and to and foot and of diabetes of patients and to disease of 2 of and 2 also to DFU of patients with diabetes foot and patients with foot of from of of DFU of and are with patients with and of patients foot their of foot and on from to with patients with with foot and foot and with foot and and of foot patients and their DFU of foot of patients and and also of of of disease and significant and of from to of and to patients with diabetes and with of and and from to and from to on from to of disease and and to to and and and to data of and foot ulcer patients with their of patients with diabetes with foot and and from to data of of of and of and with patients and of foot patients with diabetes on with to DFU of patients on on of and of foot with from to of foot patients with diabetes on with to to kidney of and of foot of of patients with and diabetes and on to of to of of and to However, foot patients and patients Diabetic and are to DFU and are of foot of and of to with and during to diabetes to from to of of to and and of of to and foot of and with foot of to of patients are on with of and patients with to with and chronic of on are and will to of and of to on and of foot of patients and and also of of of disease and significant and of from to of and to patients with diabetes and with of and and from to and from to on from to of disease and and to to and and and to data of and foot ulcer patients with their of patients with diabetes with foot and and from to data of of of and of of foot of patients and and also of of of disease and significant and of from to of and to patients with diabetes and with of and and from to and from to on from to of disease and and to to and and and to data of and foot ulcer patients with their of patients with diabetes with foot and and from to data of of of and of and with patients and of foot patients with diabetes on with to DFU of patients on on of and of foot with from to of foot patients with diabetes on with to to kidney of and of foot of of patients with and diabetes and on to of to of of and to However, foot patients and patients Diabetic and are to DFU and are of foot of and of to with and during to diabetes to from to of of to and and of of to and foot of and with foot of with patients and of foot patients with diabetes on with to DFU of patients on on of and of foot with from to of foot patients with diabetes on with to to kidney of and of foot of of patients with and diabetes and on to of to of of and to However, foot patients and patients Diabetic and are to DFU and are of foot of and of to to of patients are on with of and patients with to with and chronic of on are and will to of and of to on and to of patients are on with of and patients with to with and chronic of on are and will to of and of to on and of DFU and to to of chronic However, foot and to of data and of patients from to with of to of of foot ulcer on chronic and are with of foot and of DFU and to to of chronic However, foot and to of data and of patients from to with of to of of foot ulcer on chronic and are with of foot and

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