IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways
Peiqi Hao, Ying Huang, Jun Peng, Jiaojiao Yu, Xiao‐Xi Guo, Fan Bao, Ziqin Dian, Su An, Tian‐Rui Xu
Topics & Concepts
Cancer researchBiologyGefitinibProtein kinase BMAPK/ERK pathwayPI3K/AKT/mTOR pathwayIRS1Lung cancerTyrosine kinaseCell biologySignal transductionCancerEpidermal growth factor receptorInternal medicineEndocrinologyInsulin receptorInsulin resistanceMedicineInsulinGeneticsPI3K/AKT/mTOR signaling in cancerLung Cancer Treatments and MutationsMetabolism, Diabetes, and Cancer