Tissue‐resident memory T (T <sub>RM</sub> ) cells: Front‐line workers of the immune system
Maleika Osman, Simone L. Park, Laura K. Mackay
Abstract
Abstract Tissue‐resident memory T (T RM ) cells play a vital role in local immune protection against infection and cancer. The location of T RM cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next‐generation vaccines. Here, we discuss differential requirements for CD8 + T RM cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue‐derived factors, local antigen, and adjuvants on T RM cell generation in the context of vaccination.
Topics & Concepts
BiologyImmune systemContext (archaeology)CD8ImmunologyT cellImmunityVaccinationCytotoxic T cellGeneticsIn vitroPaleontologyT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction